|Cause of death||Shot by Richard Castle|
| Significant |
| Mrs. Holtzman (Wife) |
Two unnamed children
|Parents||Unnamed father and mother (Deceased)|
|Portrayed by||Wallace Lingham|
Dr. Van Holtzman was a respectable and well-known asylum doctor and professional psychiatrist who was also the personal shrink of Noah Lewis and secretly, a psychopathic serial killer, who targeted women and would carve ritualistic symbols on his victims' cheeks. He acted as a personal antagonist to Richard Castle as he was behind a traumatizing event which would haunt Castle for years and motivate him to become a writer.